Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice

Sing-Young Chen,Martina Beretta,Ellen M Olzomer,Divya P Shah, Derek Y H Wong,Stephanie J Alexopoulos,Isabella Aleksovska,Joseph M Salamoun,Christopher J Garcia,Blake J Cochran,Kerry-Anne Rye,Greg C Smith,Frances L Byrne,Margaret J Morris,Webster L Santos,James Cantley,Kyle L Hoehn

Molecular Metabolism（2023）

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摘要

•Mitochondrial uncoupling and calorie restriction (CR) cause negative energy balance.•This study is first to compare uncoupling and CR in a metabolic disease model.•Both treatments markedly improved metabolic disease phenotypes in db/db mice.•Despite similar weight loss, uncoupling had superior effects on glucose control.

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关键词

Calorie restriction,Mitochondrial uncoupling,Obesity,Diabetes

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