Induction of DNA strand breaks and oxidative base damages in plasmid DNA by ultra-high dose rate proton irradiation.

Teruaki Konishi,Tamon Kusumoto,Yota Hiroyama,Alisa Kobayashi,Taisei Mamiya,Satoshi Kodaira

International journal of radiation biology（2023）

引用 2|浏览9

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摘要

UHDR of a 59.5 MeV proton beam could reduce non-clustered, non-DSB damages, such as SSB and sparsely distributed ESS. However, this effect may not be significant in reducing lethal DNA damage that becomes apparent only in acute radiation effects of mammalian cells and in vivo studies.

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关键词

Protons, plasmid DNA, UHDR exposure, DNA strand breaks, oxygen depletion, radical-radical interaction

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