Cytoplasmic HMGB1 induces renal tubular ferroptosis after ischemia/reperfusion

Zhi Zhao,Guoli Li,Yuxi Wang,Yinzheng Li,Huzi Xu,Wei Liu,Wenke Hao,Ying Yao,Rui Zeng

International Immunopharmacology（2023）

引用 7|浏览29

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摘要

•HMGB1 nucleocytoplasmic translocation promoted renal inflammation and kidney injury after I/R insult.•Cytoplasmic HMGB1 induced tubular ferroptosis activation during AKI.•Binding of cytoplasmic HMGB1 to ACSL4 exacerbated kidney injury during AKI.

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关键词

HMGB1,Ferroptosis,ACSL4,Ischemia-reperfusion injury,AKI,Inflammation

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