Apolipoprotein E negatively regulates allergic airway inflammation and remodeling in mice with OVA-induced chronic asthma

Yunqin Shen, Lingjie Li, Wushi Chen,Qin Li,Yixuan Xu,Fang He,Caixia Wang,Zezhong Tian,Yanqiu Chen,Yan Yang

International Immunopharmacology（2023）

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摘要

•ApoE negatively regulates OVA-induced chronic allergic asthma in mice.•ApoE deficiency exacerbates airway remodeling in mice with OVA-induced chronic allergic asthma.•ApoE deficiency aggravates airway inflammation in mice with chronic allergic asthma.•ApoE suppressed TGF-β1 levels and Th2 responses in mice with chronic allergic asthma.

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关键词

ApoE,Airway remodeling,Chronic airway inflammation,Th2 responses

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