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Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction.

Haruka Miki,William B Kiosses,Mario C Manresa,Rinkesh K Gupta,Gurupreet S Sethi,Rana Herro,Ricardo Da Silva Antunes,Paramita Dutta,Marina Miller,Kai Fung, Ashu Chawla,Katarzyna Dobaczewska,Ferhat Ay,David H Broide,Alexei V Tumanov,Michael Croft

The Journal of allergy and clinical immunology（2023）

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摘要
LTβR signals directly and dominantly drive airway smooth muscle hyperresponsiveness relevant for pathogenesis of airway remodeling in severe asthma.
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关键词
AHR,LIGHT,LTβR,TNF superfamily,TNFSF14,airway smooth muscle,asthma,contractility,noncanonical NF-κB
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