A new parallel, rapid, and green Knoevenagel Condensation catalyzed by in-situ generated carbonic acid (CO2 (g) in water): Application to intermediate of AMG 837

Pawan Kudale,Kanchan Gavali,Dipak Pinjari,Ganesh Chaturbhuj

Results in Chemistry（2023）

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摘要

•First-ever use of carbonic water as an acid catalyst for Knoevenagel condensation.•Present method is a parallel as well as efficient, rapid, and environmentally friendly.•Method tolerates a variety of functional groups with broad substrate scope.•Green solvent with shorter reaction time and simple work-up procedure.

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关键词

Carbonic acid,Aldehydes,Active methylenes,Knoevenagel condensation

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