Multimodal In Vivo Tracking of Chimeric Antigen Receptor T Cells in Preclinical Glioblastoma Models.

Wei Emma Wu,Edwin Chang,Linchun Jin,Shiqin Liu,Ching-Hsin Huang,Rozy Kamal,Tie Liang,Nour Mary Aissaoui,Ashok J Theruvath,Laura Pisani,Michael Moseley,Tanya Stoyanova,Ramasamy Paulmurugan,Jianping Huang,Duane A Mitchell,Heike E Daldrup-Link

Investigative radiology（2022）

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摘要

MegaPro-NPs can be used for in vivo tracking of CAR T cells. Because MegaPro-NPs recently completed phase II clinical trial investigation as an MRI contrast agent, MegaPro-NP is expected to be applied to track CAR T cells in cancer immunotherapy trials in the near future.

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关键词

MegaPro iron oxide nanoparticles, glioblastoma, CAR T cells, MRI, MPI

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