A Drimane Meroterpenoid Borate as a Synchronous Ca + Oscillation Inhibitor from the Coral-Associated Fungus Alternaria sp. ZH-15.

Territrem F (), a drimane meroterpenoid bearing a unique borate ring system, was isolated together with its diol precursor territrem B () from the fungus sp. ZH-15 associated with the soft coral collected in the South China Sea. The structure of the new compound was elucidated by spectroscopic analysis and an X-ray single-crystal diffraction study, representing a new type of boron-containing natural product. Both compounds significantly inhibited spontaneous synchronous Ca oscillations (SCOs) and epileptic discharges induced by 4-aminopyridine, showing the potential for antiepileptic drug research. The 5,9-boronic ester derivative of did not change its SCO inhibitory activity.