PARP1 Inhibition and Effect on Burn Injury-Induced Inflammatory Response and Cardiac Function.

Jake J Wen,Jana E Dejesus,Geetha L Radhakrishnan,Ravi S Radhakrishnan

Journal of the American College of Surgeons（2023）

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摘要

PARP1 inhibition normalizes multiple inflammatory pathways that are altered after burn injury and improves cardiac dysfunction. PARP1 pathway inhibition may provide a novel methodology to normalize multiple burn injury-induced inflammatory pathways in the heart.

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关键词

inflammatory response,cardiac function,injury-induced

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