Hepatic Small Vessel Neoplasm Mimics Prostate Cancer on F-18-DCFPyl PET/CT

F-18-DCFPyl is a Food and Drug Administration-approved radiotracer that targets prostate-specific membrane antigen and is used in the detection of recurrent or metastatic prostate cancer. As its use has increased, a growing number of nonprostatic disease entities have been identified that express prostate-specific membrane antigen and can mimic prostate cancer. Thus, the interpreting physician must also consider other variables such as serum prostate-specific antigen levels and the distribution of uptake to avoid an inappropriate diagnosis of metastatic prostate cancer. We describe F-18-DCFPyl uptake associated with a hepatic small vessel neoplasm, an association previously undescribed in the literature.