Transient Viral Rebound in Children with Perinatally Acquired HIV-1 Induces a Unique Soluble Immunometabolic Signature Associated with Decreased CD4/CD8 Ratio.

Laura Tarancon-Diez,Joaquim Peraire,Santiago Jiménez de Ory,Maria Guirro,Luis Escosa, Luis Manuel Prieto Tato, María Penín Antón,Ana Isabel Piqueras,Álvaro Vázquez Pérez,César Gavilán,Matilde Bustillo-Alonso,María Luisa Navarro,Consuelo Viladés,Francesc Vidal,Anna Rull,María Ángeles Muñoz-Fernández

Journal of the Pediatric Infectious Diseases Society（2023）

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摘要

tVR followed by suppression implies changes in soluble proteins, lipids, and metabolites that correlate with immunological parameters, mainly ratio CD4/CD8, that decreased after tVR. These distinct soluble biomarkers could be considered potential biomarkers of immune progression.

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关键词

omics,ratio CD4/CD8,vertically HIV-1 children,viral rebounds

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