Brief Report: Suboptimal Lopinavir Exposure in Infants on Rifampicin Treatment Receiving Double-dosed or Semisuperboosted Lopinavir/Ritonavir: Time for a Change.

Tom G Jacobs,Vivian Mumbiro,Moses Chitsamatanga,Natasha Namuziya,Alfeu Passanduca,Sara Domínguez-Rodríguez,Alfredo Tagarro,Kusum J Nathoo,Bwendo Nduna,Alvaro Ballesteros,Lola Madrid,Hilda A Mujuru,Chishala Chabala,W Chris Buck,Pablo Rojo,David M Burger,Cinta Moraleda,Angela Colbers

Journal of acquired immune deficiency syndromes (1999)（2023）

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摘要

Double-dosed or semisuperboosted LPV/r for infants aged 1-12 months receiving rifampicin resulted in substantial proportions of subtherapeutic LPV levels. There is an urgent need for data on alternative antiretroviral regimens in infants with HIV/TB coinfection, including twice-daily dolutegravir.

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关键词

lopinavir, infants, rifampin, HIV, tuberculosis, drug-drug interaction

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