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Robust humoral and cellular recall responses to AZD1222 attenuate breakthrough SARS-CoV-2 infection compared to unvaccinated.

Jill Maaske,Stephanie Sproule,Ann R Falsey,Magdalena E Sobieszczyk,Anne F Luetkemeyer,Grant C Paulsen,Sharon A Riddler,Merlin L Robb, Charlotte-Paige Rolle,Beverly E Sha,Tina Tong,Bahar Ahani,Anastasia A Aksyuk,Himanshu Bansal, Timothy Egan,Brett Jepson,Marcelino Padilla, Nirmeshkumar Patel,Kathryn Shoemaker,Ann Marie Stanley,Phillip A Swanson,Deidre Wilkins,Tonya Villafana,Justin A Green,Elizabeth J Kelly

Frontiers in immunology（2022）

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摘要
Robust immune responses following AZD1222 vaccination attenuate COVID-19 disease severity and restrict SARS-CoV-2 transmission potential by reducing viral loads and the duration of viral shedding in saliva. Collectively, these analyses underscore the essential role of vaccination in mitigating the COVID-19 pandemic.
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关键词
AZD1222 (ChAdOx1 nCoV-19),COVID-19 vaccine,SARS-CoV-2,breakthrough infection,cell-mediated immunity,serology
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