Single-cell profiling reveals distinct subsets of CD14+ monocytes drive blood immune signatures of active tuberculosis.

Hannah Hillman,Nabeela Khan,Akul Singhania,Paige Dubelko,Ferran Soldevila,Rashmi Tippalagama,Aruna D DeSilva,Bandu Gunasena,Judy Perera,Thomas J Scriba,Cynthia Ontong,Michelle Fisher,Angelique Luabeya,Randy Taplitz,Gregory Seumois,Pandurangan Vijayanand,Catherine C Hedrick,Bjoern Peters,Julie G Burel

Frontiers in immunology（2022）

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摘要

Together, our study demonstrates for the first time that both intermediate and classical monocytes individually contribute to blood immune signatures of ATB and identifies novel subsets and associated gene signatures that may hold disease relevance.

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关键词

flow cytometry,immune signatures,monocytes,transcriptomics (RNA-Seq),tuberculosis

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