Perioperative corticosteroid treatment impairs tumor-infiltrating dendritic cells in patients with newly diagnosed adult-type diffuse gliomas.

Claudia Carenza,Sara Franzese,Alessandra Castagna,Sara Terzoli,Matteo Simonelli,Pasquale Persico,Lorenzo Bello,Marco Conti Nibali,Federico Pessina,Paolo Kunderfranco,Clelia Peano,Simone Balin,Joanna Mikulak,Francesca Calcaterra,Raffaella Bonecchi,Benedetta Savino,Massimo Locati,Silvia Della Bella,Domenico Mavilio

Frontiers in immunology（2022）

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摘要

Overall, the results of this study indicate that functionally impaired DCs are recruited in the glioma microenvironment. They are severely affected by dexamethasone administration, suggesting that the detrimental effects of corticosteroids on DCs may represent one of the mechanisms contributing to the already reported negative prognostic impact of steroids on glioma patient survival.

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关键词

brain tumors,dendritic cells,immune suppressive tumor microenvironment,perioperative corticosteroids,single cell-RNA sequencing

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