Effect of early postnatal supplementation of newborns with probiotic strain E. coli O83:K24:H31 on allergy incidence, dendritic cells, and microbiota.

Lenka Súkeníková,Viktor Černý,Tomáš Thon,Radka Roubalová,Zuzana Jirásková Zákostelská,Olga Novotná,Petra Petrásková,Kristýna Boráková,Ingrid Kocourková,Rája Lodinová-Žádníková,Zdeněk Musil,Libuše Kolářová,Ludmila Prokešová,Zdeněk Valenta,Jiří Hrdý

Frontiers in immunology（2022）

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摘要

Early postnatal EcO83 supplementation appears to lower allergy incidence in children of AMs. It seems that the beneficial effect of EcO83 is mediated via modulation of DC functional capacities without impacting the microbiota composition. Larger-scale studies will be necessary to confirm these preliminary findings.

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关键词

CD83,Escherichia coli O83:K24:H31,IL-10,allergy,cord blood,dendritic cell,flow cytometry,probiotic

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