Integration of single-cell and bulk transcriptomics reveals immune-related signatures in keloid.

Hanwen Wang,Ziheng Zhou,Julin Xie,Shaohai Qi,Jinming Tang

Journal of cosmetic dermatology（2023）

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摘要

In conclusion, we analyzed the cell types and functional differences in the keloid through scRNA and bulk RNA sequencing data. We identified three immune-related signatures (VCAM1, CALCRL, and HLA-DPB1) in keloid, providing a basis for further in-depth investigation of the molecular mechanisms of keloid and exploration of therapeutic targets.

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关键词

biomarker,bulk RNA sequencing,immune-related genes,keloid,single-cell RNA sequencing

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