AMPK Phosphorylates ZDHHC13 to Increase MC1R Activity and Suppress Melanomagenesis.

Yu Sun,Xin Li,Chengqian Yin,Judy Zhang,Ershang Liang,Xianfang Wu,Ying Ni,Joshua Arbesman,Colin R Goding,Shuyang Chen

Cancer research（2023）

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摘要

Phosphorylation of ZDHHC13 by AMPK at S208 promotes MC1R activation and suppresses melanocyte transformation, indicating activation of AMPK as a potential approach to prevent melanoma in people with red hair.

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关键词

mc1r activity,suppress melanomagenesis

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