Akt-mediated mitochondrial metabolism regulates proplatelet formation and platelet shedding post vasopressin exposure.

Shilei Chen, Kangfu Sun, Baichuan Xu, Songlin Han,Song Wang,Yang Xu,Fang Chen,Mo Chen,Mingqiang Shen,Yukai Lu,Changhong Du,Mengjia Hu,Fengchao Wang,Junping Wang

Journal of thrombosis and haemostasis : JTH（2023）

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摘要

these data demonstrate that phosphorylated Akt-mediated mitochondrial metabolism regulates platelet shedding from MKs in response to AVP, which will provide new therapeutic targets and further drug discovery clues for thrombocytopenia treatment.

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关键词

Akt,megakaryocyte,mitochondrial metabolism,thrombopoiesis,vasopressin

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