Narciclasine inhibits phospholipase A2 and regulates phospholipid metabolism to ameliorate psoriasis-like dermatitis.

Yi Kong,Jian Jiang,Yuqiong Huang,Xin Liu,Zilin Jin,Li Li,Fen Wei,Xinxin Liu, Jie Yin,Yonghui Zhang,Qingyi Tong,Hongxiang Chen

Frontiers in immunology（2022）

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摘要

Taken together, our findings indicate that Ncs alleviates psoriasiform skin inflammation in mice, which is associated with inhibition of PLA2 in keratinocytes and improved phospholipid metabolism. Ncs has the potential for further development as a novel anti-psoriasis drug.

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关键词

keratinocyte,lipid metabolism,narciclasine,phospholipase A2,psoriasis

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