Suppression of neurotransmission on gonadotropin-releasing hormone neurons in letrozole-induced polycystic ovary syndrome: A mouse model.

Pravin Bhattarai,Santosh Rijal,Janardhan P Bhattarai,Dong Hyu Cho,Seong Kyu Han

Frontiers in endocrinology（2022）

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摘要

These findings suggest that PCOS is an endocrine disorder that may directly affect the neurotransmitter system regulating GnRH neuronal activity at the hypothalamic level and impact reproductive physiology.

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关键词

hypothalamic-pituitary-gonadal axis,kisspeptin,letrozole,patch-clamp,polycystic ovarian syndrome,γ-amino butyric acid

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