The association of intraoperative low driving pressure ventilation and nonhome discharge: a historical cohort study

To evaluate whether intraoperative ventilation using lower driving pressure decreases the risk of nonhome discharge. We conducted a historical cohort study of patients aged ≥ 60 yr who were living at home before undergoing elective, noncardiothoracic surgery at two tertiary healthcare networks in Massachusetts between 2007 and 2018. We assessed the association of the median driving pressure during intraoperative mechanical ventilation with nonhome discharge using multivariable logistic regression analysis, adjusted for patient and procedural factors. Contingent on the primary association, we assessed effect modification by patients’ baseline risk and mediation by postoperative respiratory failure. Of 87,407 included patients, 12,584 (14.4