Modifiable risk factors for oral cavity cancer in non-smokers: A systematic review and meta-analysis

Margaret A Heller,Sarah C Nyirjesy,Robert Balsiger,Nicholas Talbot,Kyle K VanKoevering,Catherine T Haring,Matthew O Old,Stephen Y Kang,Nolan B Seim

Oral Oncology（2023）

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摘要

•Incidence of oral cavity cancer in non-smokers is increasing while risk factors for disease development in this population is poorly understood.•We performed a systematic review and meta-analysis of the existing literature.•Chewing products and various dietary, dental, and medical factors increased the risk of oral cavity cancer in non-smokers whereas alcohol was not an independent risk factor.•Further research on these non-traditional risk factors is warranted to guide clinicians in primary prevention strategies.

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关键词

Head and neck neoplasms,Squamous cell carcinoma of head and neck,Mouth neoplasms,Risk factors,Non-smokers,Primary prevention,Systematic review,Meta analysis

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