PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma.

Mengjie Zhao,Yanhui Li,Chenfei Lu,Fangshu Ding,Miao Xu,Xin Ge,Mengdie Li,Zhen Wang,Jianxing Yin,Junxia Zhang,Xiefeng Wang,Zehe Ge, Hong Xiao,Yong Xiao,Hongyi Liu, Wentao Liu, Yuandong Cao,Qianghu Wang,Yongping You,Xiuxing Wang,Kun Yang,Zhumei Shi,Xu Qian

Cancer research（2023）

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摘要

Glioma cells reduce mitochondrial biogenesis by promoting PGC1α degradation to promote resistance to radiotherapy, indicating potential therapeutic strategies to enhance radiosensitivity.

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关键词

glioma,radiation resistance

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