Skin 11β-hydroxysteroid dehydrogenase type 1 enzyme expression regulates burn wound healing and can be targeted to modify scar characteristics.

Kevin H-Y Tsai,Huaikai Shi,Roxanne J Parungao,Sina Naficy,Xiaotong Ding,Xiaofeng Ding,Jonathan J Hew,Xiaosuo Wang,Wojciech Chrzanowski,Gareth G Lavery,Zhe Li,Andrea C Issler-Fisher,Jun Chen,Qian Tan,Peter K Maitz,Mark S Cooper,Yiwei Wang

Burns & trauma（2023）

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摘要

Skin 11β-HSD1 expression is a key regulator of wound healing and scarring after burn injury. Application of an inactive glucocorticoid capable of activation by local 11β-HSD1 in skin slows the initial rate of wound closure but significantlyimproves scar characteristics post burn injury.

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关键词

11β-HSD1 knockout,Burn injury,Drug delivery,Glucocorticoid metabolism,Polycaprolactone scaffold,Scarring,Skin 11β-HSD1,Wound healing

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