Potential of RH5 Antisense on Plasmodium falciparum Proliferation Abatement.
Iranian journal of parasitology(2022)
摘要
Gemnosis delivery of a chimeric gapmer PS-ODN with 2'-OMe modifications at both sides had high antisense activity at low concentrations (10-100 nM) and shown a good efficiency to reach to target mRNA in human RBCs. Anti-parasite effect was correlated to reduction of target gene mRNA level. In addition, 2'-OMe ODNs free delivery is an effective way and does not need any carrier molecules or particles.
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关键词
Antisense,Malaria,Plasmodium falciparum
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