Design and construction of Carboxylesterase 2c Gene knockout Rats by CRISPR/Cas9.

Jie Liu,Xuyang Shang,Bingyi Yao,Yuanjin Zhang,Shengbo Huang,Yuanqing Guo,Xin Wang

Current drug metabolism（2023）

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摘要

The Ces2c KO rat model was successfully constructed by CRISPR/Cas9 system. This rat model can not only be used as an important tool to study the drug metabolism mediated by Ces2, but also as an important animal model to study the physiological function of Ces2.

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关键词

CRISPR associated protein 9,Carboxylesterase,Gene knockout techniques,Metabolism

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