A comparison of low- versus standard-dose bridging alteplase in acute ischemic stroke mechanical thrombectomy using indirect methods.

Wei Zheng,Hanhan Lei,Gareth Ambler,David J Werring,Huiying Lin,Xiaojuan Lin,Yi Tang,Jing Wu,Zhaomin Lin,Nan Liu,Houwei Du

Therapeutic advances in neurological disorders（2023）

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摘要

Indirect evidence shows that the effects of low- and standard-dose bridging alteplase are similar for key efficacy and safety outcomes. Due to the wide confidence intervals, larger randomized trials comparing low- and standard-dose alteplase bridging therapy are required.

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关键词

acute ischemic stroke,bridging alteplase therapy,dose,indirect comparisons,mechanical thrombectomy

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