Identification of signalling downstream of the transcription factor forkhead box protein M1 that protects against endoplasmic reticulum stress in a diabetic foot ulcer model.

Weixia Peng,Ting Zhu,Guangda Xiang,Ting Ding,Jun Zhao,Dan Xiong,Yaqin Zhong,Youqi Zhang

Diabetic medicine : a journal of the British Diabetic Association（2023）

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摘要

Our results revealed that FOXM1 suppressed ER stress, cell apoptosis and promoted angiogenesis in HG-induced HUVECs via mediating GAS5/TAF15/SDF4 axis, providing a novel therapeutic molecule mechanism for DFU.

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关键词

DFU,ER stress,FOXM1,GAS5,SDF4,TAF15

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