Sinomenine alleviates diabetic peripheral neuropathic pain through inhibition of the inositol-requiring enzyme 1 alpha-X-box binding protein 1 pathway by downregulating prostaglandin-endoperoxide synthase 2.

Ji Chen, Peng Guo,Xinxin Liu, Huizhi Liao,Kemin Chen,Yuxia Wang,Jie Qin,Fengrui Yang

Journal of diabetes investigation（2023）

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摘要

SIN decreases the expression of PTGS2 to inactivate the inositol-requiring enzyme 1 alpha-X-box binding protein 1 signaling pathway, which inhibits microglial activation, as well as the release of inflammatory factors, thus alleviating DPNP.

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关键词

Diabetic peripheral neuropathic pain,Sinomenine,Spinal cord microglia

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