Discovery and Characterization of the Covalent SARS-CoV-2 3clpro Inhibitors from Ginkgo Biloba Extract Via Integrating Chemoproteomic and Biochemical Approaches

Collectively, GBE50 and some constituents in this herbal product could strongly inhibit SARS-CoV-2 3CL in dose- and time-dependent manner. Gallocatechin and sciadopitysin were identified as potent SARS-CoV-2 3CL inhibitors, which offers promising lead compounds for the development of novel anti-SARS-CoV-2 drugs.