Electrifying Continuous-Flow Platform for Coupling Reaction and Anti-Viral Daclatasvir API Synthesis

A novel nanotextured Ni@Cu material embedded electro micro-flow reactor with minimal electrode distance has been employed to synthesize biphenyls via the construction of a new C–C bond. The reported protocol is devoid of noble metal and involves co-reductant/oxidant-free conditions in a fast manner for the synthesis of substituted/unsubstituted biphenyl systems. The electro-reactor volume has been optimized for the gram scale biphenyl synthesis and further extended for an integrated total process system reducing the tedious downstream process by selective removal of unwanted chemicals/solvent. The continuous micro-flow synthesis of daclatasvir is now accomplished with a good yield.