Birth incidence and outcome of harlequin ichthyosis and collodion membrane in the UK and Ireland: a national 2-year prospective surveillance study.

Collodion membrane covers a heterogeneous group of ichthyoses with disparate outcomes. In this large, prospective birth-cohort study we show that babies with non-syndromic collodion membrane are born in good condition and in 40% the ichthyosis resolves within a year. Our data challenges existing guidelines and supports expectant management.