Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy in Patients With Metastatic Colorectal Cancer With Measures of Microsatellite Instability, Mismatch Repair, or Tumor Mutational Burden.

Julia C F Quintanilha,Ryon P Graf,Virginia A Fisher,Geoffrey R Oxnard,Haley Ellis,Nicole Panarelli,Douglas I Lin,Gerald Li,Richard S P Huang,Jeffrey S Ross,Parvathi A Myer,Samuel J Klempner

JAMA network open（2023）

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摘要

In this comparative effectiveness research study, MSI assessed by NGS robustly identified patients with favorable outcomes on first-line ICIs vs chemotherapy and appeared to better anticipate ICI outcomes compared with DMMR.

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关键词

immune checkpoint inhibitors,metastatic colorectal cancer,colorectal cancer,tumor mutational burden,microsatellite instability

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