Pharmacokinetics of cannabidiol following single oral and oral transmucosal administration in dogs.

Giorgia Della Rocca,Fabiola Paoletti,Maria Beatrice Conti,Roberta Galarini,Elisabetta Chiaradia,Monica Sforna,Cecilia Dall'Aglio,Angela Polisca,Alessandra Di Salvo

Frontiers in veterinary science（2022）

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摘要

The OTM administration did not increase cannabidiol bioavailability compared to oral treatment. The almost perfectly superimposable mean plasma concentrations of cannabidiol following the two treatments suggests that CBD is not able to be adsorbed by the oral mucosa or that its absorption is very scarce, and that CBD is swallowed and absorbed in the gastrointestinal tract.

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关键词

CBD,OTM,cannabidiol,dog,oral administration,oral transmucosal administration,pharmacokinetics

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