The Impact of Zinc on Manganese Bioavailability and Cytotoxicity in HepG2 Cells.

Vivien Michaelis, Silja Kasper, Lisa Naperkowski, Jan Pusse,Alicia Thiel,Franziska Ebert,Michael Aschner,Tanja Schwerdtle,Hajo Haase,Julia Bornhorst

Molecular nutrition & food research（2023）

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摘要

Zn protects against Mn-induced cytotoxicity in HepG2 cells possibly due to decreased Mn bioavailability. Additionally, mRNA expression of metal homeostasis-related genes indicates possible underlying pathways that should to be addressed in future studies.

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关键词

HepG2,manganese,trace element homeostasis,trace element transport,zinc

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