Praziquantel target validation of a Ca 2+ permeable channel in schistosomes.

Cell calcium（2023）

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摘要

•Schistosomiasis is a devastating neglected helminthic disease.•Praziquantel (PZQ) is the most important drug against schistosomiasis.•Previous work identified a TRP channel of the melastatin type as a PZQ target.•Molecular studies now reveal the basis for varied PZQ sensitivity of different helminths.

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关键词

Calcium channel,Drug target,Praziquantel,Transient receptor potential melastatin

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