Identifying clinically useful biomarkers in neurodegenerative disease through a collaborative approach: the NeuroToolKit.

Sterling C. Johnson,Marc Suárez-Calvet,Ivonne Suridjan,Carolina Minguillón,Juan Domingo Gispert,Erin Jonaitis,Agata Michna,Margherita Carboni,Tobias Bittner,Christina Rabe,Gwendlyn Kollmorgen,Henrik Zetterberg,Kaj Blennow

Alzheimer's research & therapy（2023）

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摘要

The precision of the NTK enables merging of biomarker datasets, after correction for preanalytical confounders. Assessment of multiple cohorts is crucial to increase power in future studies into AD pathogenesis.

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关键词

Alzheimer’s disease,Amyloid-β,Cerebrospinal fluid biomarkers,Glial activation,Inflammation,Neurodegeneration

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