Distribution of cholinergic nerve terminals in the aged human brain measured with [ 18 F]FEOBV PET and its correlation with histological data.

Niels Okkels,Jacob Horsager,Miguel A Labrador-Espinosa,Frederik O Hansen,Katrine B Andersen,Mie Kristine Just,Tatyana D Fedorova,Casper Skjærbæk,Ole L Munk,Kim V Hansen,Hanne Gottrup,Allan K Hansen,Michel J Grothe,Per Borghammer

NeuroImage（2023）

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摘要

Our in vivo findings confirm the regional cholinergic distribution in specific brain structures as described post-mortem. A positive spatial correlation between tracer distribution and regional gene expression levels further corroborates [F]FEOBV PET as a validated tool for in vivo cholinergic imaging. The study represents an advancement in the continued efforts to delineate the spatial topography of the human cholinergic system in vivo.

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关键词

Brain,Cholinergic Neurons,Healthy Volunteer,PET-CT,VAChT Proteins,mRNA

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