Anti-Kv1.4 Antibody Without Myasthenia Gravis

Naoto Kuyama, MD, Seiji Takashio, MD, PhD, Takumi Nagakura, MD, Michie Imamura, MD, Koutaro Takamatsu, MD, PhD, Masafumi Takae, MD, PhD, Kyoko Hirakawa, MD, PhD, Kenshi Yamanaga, MD, PhD, Shinsuke Hanatani, MD, PhD, Eiichiro Yamamoto, MD, PhD, Kenichi Matsushita, MD, PhD, Mitsuharu Ueda, MD, PhD, Kenichi Tsujita, MD, PhD

JACC: Case Reports（2023）

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摘要

Anti-Kv1.4 antibody is often detected in thymoma-associated myasthenia gravis patients with anti-acetylcholine receptor antibody. Herein, we describe 2 patients with concurrent myocarditis and myositis. In both cases, anti-Kv1.4 antibody was positive despite the absence of thymoma and anti-acetylcholine receptor antibody, and immunosuppressants eventually resolved their symptoms and cardiac function. (Level of Difficulty: Advanced.)

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anti-Kv1.4 antibody,myasthenia gravis,myocarditis,myositis

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