Novel N(SCF3)(CF3)-Amines: Synthesis, Scalability and Stability

We disclosed herein a straightforward strategy for the synthesis of unprecendented N-((trifluoromethyl)thio), N-(trifluoromethyl) amines using a combination of isothiocyanates with a fluoride source and an electrophilic trifluoromethylthiolation reagent. More interestingly, the scalability of the methodology has been demonstrated and the stability of the new motif has been studied.