Up-regulation of oxytocin receptors on peripheral sensory neurons mediates analgesia in chemotherapy-induced neuropathic pain.

Lixuan Li,Pupu Li,Jing Guo,Yifei Wu,Qian Zeng,Nan Li,Xiaoting Huang,Yongshen He,Wen Ai,Wuping Sun,Tao Liu,Donglin Xiong,Lizu Xiao,Yanyan Sun,Qiming Zhou,Haixia Kuang,Zilong Wang,Changyu Jiang

British Journal of Pharmacology（2023）

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摘要

The OXTR in small-sized DRG neurons is up-regulated in CINP and its activation relieved CINP by inhibiting the neural excitability by impairment of Na 1.7 currents via pPKC. Our results suggest that OXTR on peripheral sensory neurons is a potential therapeutic target to relieve CINP.

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关键词

chemotherapy-induced peripheral neuropathic pain,oxytocin,oxytocin receptor,paclitaxel

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