Contribution of voriconazole N-oxide plasma concentration measurements to voriconazole therapeutic drug monitoring in patients with invasive fungal infection.

Christelle Boglione‐Kerrien,Jeff Morcet,Lucie‐Marie Scailteux,François Bénézit,Christophe Camus,Jean‐Baptiste Mear,Jean‐Pierre Gangneux,Eric Bellissant,Camille Tron,Marie‐Clémence Verdier,Florian Lemaitre

Mycoses（2023）

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摘要

Measurement of NOX resulted useful for TDM of patients treated with VRC. The MR using NOX informed interpretation and clinical decision-making and is very interesting for complex patients. VRC phenotyping based on the MR is now performed routinely in our institution. A dosing algorithm has been suggested from these results.

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关键词

Antifungal,invasive fungal infection,metabolic ratio,pharmacokinetic variability,phenotyping,therapeutic drug monitoring,voriconazole,voriconazole N-oxide

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