Management of Skin Cancer in the Immunocompromised Patient

Non-melanoma skin cancer represents the most common form of cancer in humans. Cutaneous squamous cell carcinoma is second most common form behind basal cell carcinoma and is the most common type of cancer with significant metastatic potential. Immunosuppressed patients, including solid organ transplant recipients and those with human immunodeficiency virus infection, are at significantly elevated risk of cutaneous squamous cell carcinoma. This chapter discusses the incidence, presentation, diagnosis and management of non-melanoma skin cancer in patients with immunosuppression, with particular focus on the key areas of the management strategy that differ when compared to management of immunocompetent patients.