JAK inhibitors differentially modulate B cell activation, maturation and function: A comparative analysis of five JAK inhibitors in an in-vitro B cell differentiation model and in patients with rheumatoid arthritis.

Natalie Frede,Raquel Lorenzetti, Janika M Hüppe,Iga Janowska,Arianna Troilo,Marei-Theresa Schleyer,Ana C. Venhoff,Reinhard E. Voll,Jens Thiel,Nils Venhoff,Marta Rizzi

Frontiers in immunology（2023）

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摘要

JAK inhibition has a major effect on B cell activation and differentiation, with differential outcomes between JAK inhibitors hinting towards distinct and unique effects on B cell homeostasis.

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关键词

B cells,JAK inhibition,baricitinib,filgotinib,rheumatoid arthritis,ruxolitinib,tofacitinib,upadacitinib

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