Highly Sensitive Multi-Channel Biosensor for Low-Interference Simultaneous Detection.

In this paper, we propose a multi-channel photonic crystal fiber sensor, which adopts dual-polarization and multiple materials to effectively reduce the mutual interference between channels and enhance the surface plasmon resonance, thus achieving simultaneous detection of a multi-channel with low interference. Four channels are polished around the cylindrical fiber, and then different metal films (gold or silver) and plasmonic materials (titanium dioxide, thallium pentoxide, or graphene) are added to the sensing area of each channel. All channels detect refractive indices in the range of 1.34 to 1.42. The sensing performance of the fiber optic sensor was numerically investigated using the full vector finite element method. After the optimization of structural parameters, the maximum wavelength sensitivity of channel-1, channel-2, channel-3, and channel-4 are 49,800 nm/RIU, 49,000 nm/RIU, 35,900 nm/RIU, and 36,800 nm/RIU, respectively. We have theoretically analyzed the sensor's capabilities for partial bio-detection and simulated its detection capability with a wavelength sensitivity of 11,500 nm/RIU for normal red blood cells and 12,200 nm/RIU for MCF-7 cancerous cells. Our proposed sensor has a novel design, can detect multiple channels simultaneously, has strong anti-interference capability and high sensitivity, and has good sensing characteristics.