Cardiovascular risk factor reporting in immune checkpoint inhibitor trials: A systematic review

Reporting of cardiovascular risk factors in immune checkpoint inhibitor trials. Cardiovascular risk factors are poorly defined in landmark immune checkpoint inhibitor trials. Each trial included in the systematic review is represented in the figure by their trial name (CM – CheckMate trial, KN – KEYNOTE trial). Trials with cardiac exclusion factors are listed on right of the dotted line. Trials that reported prevalence of smoking are depicted in the red bubble, BMI in the blue bubble, and hypertension, dyslipidemia and diabetes in the yellow bubble. Only one trial reported all conventional cardiovascular risk factors at baseline (overlap of red, blue and yellow bubbles). Trials that did not report any cardiovascular risk factors are depicted outside the coloured bubbles. Trials which utilized concurrent cardiotoxic vascular endothelial growth factor inhibitors are highlighted in red font. A complete list of the included trials are available in the Supplementary appendix. *Adjuvant trials. **Neoadjuvant trials. BMI – Body mass index, CM – CheckMate, KN – KEYNOTE.ga1