Impact of the HLA Immunopeptidome on Survival of Leukemia Patients After Unrelated Donor Transplantation.

Pietro Crivello,Esteban Arrieta-Bolaños,Meilun He,Tao Wang,Stephanie Fingerson,Shahinaz M Gadalla,Sophie Paczesny,Steven G E Marsh,Stephanie J Lee,Stephen R Spellman,Yung-Tsi Bolon,Katharina Fleischhauer

Journal of clinical oncology : official journal of the American Society of Clinical Oncology（2023）

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摘要

PBM-GVH mismatches inform mortality risks after single class I HLA-mismatched UD-HCT, suggesting that prospective consideration of directional PBM-matching status might improve outcome. These findings highlight immunopeptidome divergence between mismatched HLA as a driver of clinical tolerability in UD-HCT.

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关键词

hla immunopeptidome,leukemia patients,transplantation

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