COVID-19 mRNA vaccine immunogenicity decay and breakthrough illness in adolescents and young adults with childhood-onset rheumatic diseases.

Joo Guan Yeo,Kai Liang Teh,Wan Ni Chia,Yun Xin Book,Sook Fun Hoh,Xiaocong Gao,Lena Das,Jinyan Zhang,Nursyuhadah Sutamam,Su Li Poh,Amanda Jin Mei Lim,Shi Huan Tay,Katherine Nay Yaung,Xin Mei Ong,Jing Yao Leong,Lin-Fa Wang,Salvatore Albani,Thaschawee Arkachaisri

Rheumatology (Oxford, England)（2023）

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摘要

Over half of AYAs with cRDs had a significant drop in SARS-CoV-2 nAb at 6-month despite an initial robust humoral response. JIA and aTNF usage are predictors of a faster decay rate.

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关键词

COVID vaccine,COVID-19 infection,SARS-CoV-2,childhood-onset rheumatic diseases,vaccine effectiveness

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