Neuroprotective effects of nobiletin on cerebral ischemia/reperfusion injury rats by inhibiting Rho/ROCK signaling pathway.

Dan Huang,Jiaping Qin, Na Lu,Zongjun Fu,Bo Zhang,Shuhong Tian,Qiang Liu

Annals of translational medicine（2022）

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摘要

Nobiletin had a neuroprotective effect in rats with cerebral I/R injury, and its potential mechanism is decreasing neuron apoptosis by inhibiting the Rho/ROCK signaling pathway. These results suggest NOB is a promising neuroprotective agent for patients with cerebral ischemia.

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关键词

Cerebral ischemia/reperfusion injury (cerebral I/R injury),Rho/ROCK signaling pathway,neuroprotective agents,nobiletin

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